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GHS Mixture ATE Calculator

Acute toxicity (oral, dermal, inhalation) mixture classification only, per GHS Purple Book Chapter 3.1. This calculator does not cover skin corrosion, aquatic hazards, or STOT endpoints.

Ingredients

Ingredients below 1% concentration are excluded from the additivity sum. Unknown ingredients above 10% of the mixture trigger the corrected additivity formula.

ATEmix (mg/kg bw) =

19.802

GHS Category 2 — H300 Fatal if swallowed

Assumption: only ingredients ≥1% concentration are included in the additivity sum.

UN GHS Rev.10 §3.1.3.6, Tables 3.1.1-3.1.2 (verified against the primary text) — as of 2026-07-12. UNECE GHS

Reference only. Not legal or regulatory advice. Verify against the primary source before you act.

How it works

This calculator applies the UN GHS acute-toxicity-estimate (ATE) additivity formula to classify a mixture from its ingredients:

  • 100 / ATEmix = Σ (Ci / ATEi) over ingredients at or above the relevance cutoff
  • If unknown ingredients exceed 10% of the mixture: (100 − ΣCunknown) / ATEmix = Σ (Ci / ATEi)

Scope: acute toxicity (oral, dermal, inhalation-gas, inhalation- vapour, inhalation-dust/mist) only. This calculator does not cover skin corrosion, aquatic hazards, or STOT endpoints. Only the Oral route has populated category and conversion tables in this build — other routes are refused pending founder primary-source verification.

UN GHS Rev.10 §3.1.3.6, Tables 3.1.1-3.1.2 (verified against the primary text) — UNECE GHS · as of 2026-07-12.

Worked example

Two oral-toxicity ingredients: 50% at ATE 10 mg/kg, 50% at ATE 1000 mg/kg.

100 / (50/10 + 50/1000) = 100 / 5.05 = 19.8 mg/kg — Category 2 (H300, Fatal if swallowed).

Sources

  • Acute toxicity estimate tables and the additivity formula

    United Nations Economic Commission for Europe (UNECE), as of 2026-07-12

    UN GHS Rev.10 §3.1.3.6, Tables 3.1.1-3.1.2 (verified against the primary text)

    open the source

Related tools

Data vintage

  • Data: GHS acute toxicity estimate tables, United Nations Economic Commission for Europe (UNECE) ST/SG/AC.10/30/Rev.10, English edition, retrieved 2026-07-12.Category boundaries and point estimates for five exposure routes, not a substance list, so no entry count applies.

last updated 2026-07-12